glass and petrol

I leaned on the wall and the wall leaned away

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skunkbear:

How Mouse Studies Lead Medical Research Down Dead Ends
Most experimental drugs fail before they make it through all the tests required to figure out if they actually work and if they’re safe. But some drugs get fairly far down that road, at the cost of hundreds of millions of dollars, based on poorly conducted studies at the outset.
Medical researchers reviewing this sorry state of affairs say the drug-development process needs serious improvement.
Consider drugs that are being developed to treat Lou Gehrig’s disease. In the past decade or so, nine potential drugs have been tested in people who have this degenerative nerve disorder. Not one has been effective.
So Steve Perrin, who runs the ALS Therapy Development Institute in Cambridge Mass., decided to take a close look at the mouse studies that had initially suggested these drugs were promising.
"We tried to replicate those findings precisely by talking to the authors and trying to repeat the experiments in an identical fashion," Perrin says. "And what we found was that we couldn’t replicate a lot of the experiments."
Keep reading.
Image: Rick Eh?, Flickr

skunkbear:

How Mouse Studies Lead Medical Research Down Dead Ends

Most experimental drugs fail before they make it through all the tests required to figure out if they actually work and if they’re safe. But some drugs get fairly far down that road, at the cost of hundreds of millions of dollars, based on poorly conducted studies at the outset.

Medical researchers reviewing this sorry state of affairs say the drug-development process needs serious improvement.

Consider drugs that are being developed to treat Lou Gehrig’s disease. In the past decade or so, nine potential drugs have been tested in people who have this degenerative nerve disorder. Not one has been effective.

So Steve Perrin, who runs the ALS Therapy Development Institute in Cambridge Mass., decided to take a close look at the mouse studies that had initially suggested these drugs were promising.

"We tried to replicate those findings precisely by talking to the authors and trying to repeat the experiments in an identical fashion," Perrin says. "And what we found was that we couldn’t replicate a lot of the experiments."

Keep reading.

Image: Rick Eh?, Flickr